Turgeon S M, Case L C
Department of Psychology Amherst College, Amherst, MA 01002, USA.
Brain Res. 2001 Jan 12;888(2):302-305. doi: 10.1016/s0006-8993(00)03056-0.
Previous data demonstrate that a single injection of phencyclidine enhances amphetamine-induced behaviors 24 h later, suggesting that the delayed effects of a single dose of phencyclidine may produce a schizophrenia-like state in animals. These behavioral changes were accompanied by altered patterns of c-Fos induction, suggesting possible neurochemical correlates to the observed behaviors. Because investigations into PCP's ability to model schizophrenia have found that the effects of repeated, or subchronic, PCP administration differ according to the dose and administration paradigm, this study sought to determine whether single and subchronic PCP exposure produce different effects on amphetamine-induced behaviors and c-Fos induction. No differences were observed between these administration paradigms; both single and subchronic PCP exposure enhanced amphetamine-induced c-Fos in the striatum, decreased c-Fos in the prefrontal cortex, and decreased the number of cage-crossings. However, the observation that PCP pretreatment affected c-Fos induction in the same manner observed previously while having an opposite effect on amphetamine-induced behavior suggests that these behavioral and neurochemical effects are dissociated.
先前的数据表明，单次注射苯环己哌啶会在24小时后增强苯丙胺诱导的行为，这表明单剂量苯环己哌啶的延迟效应可能会在动物身上产生类似精神分裂症的状态。这些行为变化伴随着c-Fos诱导模式的改变，这表明观察到的行为可能存在神经化学相关性。由于对苯环己哌啶模拟精神分裂症能力的研究发现，重复或亚慢性给予苯环己哌啶的效果会因剂量和给药模式而异，因此本研究旨在确定单次和亚慢性接触苯环己哌啶是否会对苯丙胺诱导的行为和c-Fos诱导产生不同影响。在这些给药模式之间未观察到差异；单次和亚慢性接触苯环己哌啶均增强了纹状体中苯丙胺诱导的c-Fos，减少了前额叶皮质中的c-Fos，并减少了穿越笼子的次数。然而，苯环己哌啶预处理以先前观察到的相同方式影响c-Fos诱导，但对苯丙胺诱导的行为产生相反影响，这一观察结果表明这些行为和神经化学效应是分离的。
