Collard J M, Romagnoli R
Department of Surgery, Louvain Medical School, Brussels, Belgium.
Eur J Surg. 2000 Dec;166(12):942-8. doi: 10.1080/110241500447100.
To discover whether the human stomach contracts every 20 seconds or not.
Manometric study.
Teaching hospital, Belgium.
10 healthy volunteers, and 31 patients who had had the whole stomach denervated and pulled up to the neck for oesophageal replacement.
Analysis of selected strips of manometric tracings obtained with intraluminal perfused catheters. 13 patients were given erythromycin (1g/day) by mouth.
Estimation of the rate and frequency distribution according to amplitude of intraluminal pressure waves with the vertical axis of the tracings scaled up to reflect contractions within the gastric wall.
Microwaves (<9 mmHg) that came in between conventional macrowaves (>9 mmHg) were found, showing that the human stomach undergoes mechanical activity (amplitude ranging from 0.2-310 mmHg) at the pacemaker's rate which varied from 2.43 to 3.60 cycles/minute from one subject to another. Phase I of the interdigestive motor complex contained microwaves only, phase II and the fed pattern consisted of a mixture of microwaves and macrowaves, and phase III contained macrowaves only. The fasting rate of mechanical activity was lower in patients who were given erythromycin than in those not given erythromycin (p = 0.003) and in healthy volunteers (p = 0.002), and it increased significantly after a meal (p < 0.0001). Microwaves in strips in which they were the most prominent were of higher amplitude in patients than in healthy volunteers (median: 3.5 compared with 2.5 mmHg; p < 0.0001).
The human stomach has mechanical activity at the rate at which the pacemaker generates electrical slow waves. The classic phases of the gastric motor activity seem to differ from each other by the frequency distribution of pressure waves according to amplitude rather than by the contraction rate. Weak mechanical activity is much more readily detectable after the stomach has been denervated and tailored for oesophageal substitution.
探究人类胃部是否每20秒收缩一次。
测压研究。
比利时教学医院。
10名健康志愿者以及31名因食管置换而将整个胃去神经支配并上提到颈部的患者。
分析通过腔内灌注导管获得的测压描记图的选定条带。13名患者口服红霉素（1克/天）。
根据腔内压力波的幅度估计速率和频率分布，将描记图的纵轴放大以反映胃壁内的收缩情况。
发现介于传统大波（>9 mmHg）之间的微波（<9 mmHg），表明人类胃部以起搏器速率进行机械活动（幅度范围为0.2 - 310 mmHg），不同个体之间的起搏器速率在2.43至3.60次/分钟之间变化。消化间期移行性复合运动的I期仅包含微波，II期和进食模式由微波和大波混合组成，III期仅包含大波。服用红霉素的患者的空腹机械活动速率低于未服用红霉素的患者（p = 0.003）以及健康志愿者（p = 0.002），且进食后显著增加（p < 0.0001）。微波在其中最为突出的条带中，患者的微波幅度高于健康志愿者（中位数：3.5 mmHg与2.5 mmHg相比；p < 0.0001）。
人类胃部以起搏器产生电慢波的速率进行机械活动。胃运动活动的经典阶段似乎因压力波根据幅度的频率分布而非收缩速率而彼此不同。在胃去神经支配并用于食管替代后，更容易检测到微弱的机械活动。
