Daniel D G
Department of Psychiatry and Behavioral Sciences, George Washington University, Washington, DC, USA.
J Clin Psychiatry. 2000;61 Suppl 14:49-52.
Agitated, aggressive behavior and psychosis are common manifestations of Alzheimer's disease that frequently lead to institutionalization. The usefulness of conventional neuroleptic treatment in this population is limited by narrow therapeutic windows because of limited efficacy and high sensitivity to side effects. More recently, investigational clinical trials have suggested potential utility for atypical antipsychotics such as risperidone, olanzapine, and quetiapine in treatment of behaviorally disturbed individuals and for the psychotic manifestations of dementia.
激越、攻击行为和精神病是阿尔茨海默病的常见表现，常导致患者被送入医疗机构。由于疗效有限且对副作用高度敏感，传统抗精神病药物治疗在这一人群中的效用受到狭窄治疗窗的限制。最近，研究性临床试验表明，非典型抗精神病药物如利培酮、奥氮平和喹硫平在治疗行为紊乱个体以及痴呆的精神病性表现方面可能有用。
