通过靶向破坏精氨酸酶II基因生成精氨酸酶II缺乏的小鼠模型。
Generation of a mouse model for arginase II deficiency by targeted disruption of the arginase II gene.
作者信息
Shi O, Morris S M, Zoghbi H, Porter C W, O'Brien W E
机构信息
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA.
出版信息
Mol Cell Biol. 2001 Feb;21(3):811-3. doi: 10.1128/MCB.21.3.811-813.2001.
Abstract
Mammals express two isoforms of arginase, designated types I and II. Arginase I is a component of the urea cycle, and inherited defects in arginase I have deleterious consequences in humans. In contrast, the physiologic role of arginase II has not been defined, and no deficiencies in arginase II have been identified in humans. Mice with a disruption in the arginase II gene were created to investigate the role of this enzyme. Homozygous arginase II-deficient mice were viable and apparently indistinguishable from wild-type mice, except for an elevated plasma arginine level which indicates that arginase II plays an important role in arginine homeostasis.
摘要
哺乳动物表达两种精氨酸酶同工型，分别称为I型和II型。精氨酸酶I是尿素循环的一个组成部分，精氨酸酶I的遗传性缺陷在人类中会产生有害后果。相比之下，精氨酸酶II的生理作用尚未明确，且在人类中尚未发现精氨酸酶II缺乏的情况。为了研究这种酶的作用，构建了精氨酸酶II基因缺失的小鼠。纯合精氨酸酶II缺陷型小鼠能够存活，除了血浆精氨酸水平升高外，与野生型小鼠明显无异，这表明精氨酸酶II在精氨酸稳态中起重要作用。
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本文引用的文献
1
Arginine metabolism: nitric oxide and beyond.
Biochem J. 1998 Nov 15;336 ( Pt 1)(Pt 1):1-17. doi: 10.1042/bj3360001.
2
Structure of the murine arginase II gene.
Mamm Genome. 1998 Oct;9(10):822-4. doi: 10.1007/s003359900874.
3
Cloning and characterization of the mouse and rat type II arginase genes.
Mol Genet Metab. 1998 Mar;63(3):168-75. doi: 10.1006/mgme.1997.2669.
4
Human type II arginase: sequence analysis and tissue-specific expression.
Gene. 1997 Jul 9;193(2):157-61. doi: 10.1016/s0378-1119(97)00099-1.
5
Cloning and characterization of the human type II arginase gene.
Genomics. 1996 Dec 1;38(2):118-23. doi: 10.1006/geno.1996.0606.
6
Molecular cloning of cDNA for nonhepatic mitochondrial arginase (arginase II) and comparison of its induction with nitric oxide synthase in a murine macrophage-like cell line.
FEBS Lett. 1996 Oct 21;395(2-3):119-22. doi: 10.1016/0014-5793(96)01015-0.
7
Comparative properties of arginases.
Comp Biochem Physiol B Biochem Mol Biol. 1996 May;114(1):107-32. doi: 10.1016/0305-0491(95)02138-8.
8
Plasma arginine and citrulline kinetics in adults given adequate and arginine-free diets.
Proc Natl Acad Sci U S A. 1993 Aug 15;90(16):7749-53. doi: 10.1073/pnas.90.16.7749.
9
Arginine becomes an essential amino acid after massive resection of rat small intestine.
J Biol Chem. 1994 Dec 23;269(51):32667-71.
10
Urea cycle intermediate kinetics and nitrate excretion at normal and "therapeutic" intakes of arginine in humans.
Am J Physiol. 1995 Nov;269(5 Pt 1):E884-96. doi: 10.1152/ajpendo.1995.269.5.E884.
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