Petersen F C, Scheie A A
Department of Oral Biology, Dental Faculty, University of Oslo, P.O. Box 1052 Blindern, N-0316 Oslo, Norway.
Oral Microbiol Immunol. 2000 Oct;15(5):329-34. doi: 10.1034/j.1399-302x.2000.150511.x.
Competence for genetic transformation in Streptococcus pneumoniae and Streptococcus gordonii involves the ComAB secretion apparatus, which is thought to export the competence-stimulating peptide. Homologous secretory systems are also used for the export of certain bacteriocins and bacteriocin-like peptides. In this study, a similar secretory apparatus was found in the Streptococcus mutans genome, and its role in transformation was investigated. Gene inactivation resulted in a mutant deficient in transformability. We suggest that secretion of a peptide, possibly the competence-stimulating peptide itself, is involved in competence induction also in S. mutans.
肺炎链球菌和戈登氏链球菌中的遗传转化能力涉及ComAB分泌装置，该装置被认为可输出感受态刺激肽。同源分泌系统也用于某些细菌素和类细菌素肽的输出。在本研究中，在变形链球菌基因组中发现了类似的分泌装置，并研究了其在转化中的作用。基因失活导致了一个转化能力缺陷的突变体。我们认为，一种肽（可能是感受态刺激肽本身）的分泌也参与了变形链球菌的感受态诱导。
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