表现为Riedel甲状腺炎的多灶性特发性纤维硬化症。

Multifocal idiopathic fibrosclerosis manifesting with Riedel's thyroiditis.

作者信息

Tütüncü N B, Erbas T, Bayraktar M, Gedik O

机构信息

Department of Internal Medicine, Endocrinology and Metabolism, Hacettepe University, Sancak Mahallesi 221, Sokak, No:5/10, Yildiz 06550, Ankara, Turkey.

出版信息

Endocr Pract. 2000 Nov-Dec;6(6):447-9.

PMID:11155216

Abstract

OBJECTIVE

To discuss our experience with a case of Riedel's thyroiditis manifesting in conjunction with several other fibrosclerotic lesions.

METHODS

We describe a case of multifocal fibrosclerosis and its response to glucocorticoid therapy.

RESULTS

A 46-year-old man with dyspnea, dysphagia, and hoarseness was found to have Riedel's thyroiditis, sclerosing cholangitis, retroperitoneal fibrosis, and renal cortical fibrosis. Treatment with high-dose glucocorticoids in the early stages of the disease and maintenance therapy with low-dose glucocorticoids in later stages of the disease had a beneficial effect. Serial follow-up assessments with determination of the erythrocyte sedimentation rate and computed tomographic imaging of the abdomen and thorax are recommended for monitoring of disease activity.

CONCLUSION

Glucocorticoids are currently the treatment of choice for progressive multifocal fibrosclerosis. Accumulation of further clinical data is needed to determine more precise treatment strategies.

摘要

目的

探讨1例合并其他几种纤维硬化性病变的Riedel甲状腺炎病例的诊疗经验。

方法

我们描述了1例多灶性纤维硬化症病例及其对糖皮质激素治疗的反应。

结果

一名46岁男性，有呼吸困难、吞咽困难和声音嘶哑症状，被诊断为Riedel甲状腺炎、硬化性胆管炎、腹膜后纤维化和肾皮质纤维化。在疾病早期给予高剂量糖皮质激素治疗，后期给予低剂量糖皮质激素维持治疗，取得了良好效果。建议通过定期随访评估红细胞沉降率，并进行腹部和胸部计算机断层扫描成像，以监测疾病活动情况。