Evdokimov Iu V, Golo V L, Salianov V I, Lortkipanidze G B, Kats E I
Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, ul. Vavilova 32, Moscow, 117984 Russia.
Biofizika. 2000 Nov-Dec;45(6):1029-38.
The properties of mesomorphic dispersions of double-stranded nucleic acids were studied. A comparison of these properties indicates that their diversity cannot be explained unambiguously in terms of the conception of Van-der-Waals interactions in particles of mesomorphic dispersions without regard for the specific properties of the solvent, water, in the vicinity of adjacent nucleic acid molecules. It was assumed that, with small distances between the molecules of nucleic acids, a specific "phantom" structure of the solvent appears in their vicinity, which acts as an elastic medium that modifies the interactions between nucleic acid molecules and as a medium in which a collective tunneling of protons can occur. The combination of the two effects determines the "recognition" of nucliec acid molecules and the stabilization of the cholesteric structure of mesomorphic dispersions of nucleic acids.
对双链核酸介晶分散体的性质进行了研究。对这些性质的比较表明,若不考虑相邻核酸分子附近溶剂(水)的特殊性质,仅依据介晶分散体颗粒中范德华相互作用的概念,无法明确解释它们的多样性。据推测,当核酸分子间距离较小时,其附近会出现一种特殊的溶剂“幻影”结构,它作为一种弹性介质改变核酸分子间的相互作用,同时也是质子能够发生集体隧穿的介质。这两种效应的结合决定了核酸分子的“识别”以及核酸介晶分散体胆甾相结构的稳定。