Nunes J S, Correia L G, Corrêa J N
Unidade de Endocrinologia, Hospital Curry Cabral, Lisboa.
Acta Med Port. 2000 Jul-Aug;13(4):203-10.
The western way of life favours the development of a state of insulin resistance, in genetically predisposed subjects. In this state, greater levels of insulin are necessary so that an answer can be obtained and, consequently, hyperinsulinism occurs. Insulin has several target tissues, thus insulin resistance is associated with the dysfunction of a multiplicity of tissues, organs and systems in the body (Syndrome X). All of those dysfunctions together with hyperinsulinism can greatly enhance the risk of atherosclerotic vascular disease. In this article we review the dysfunction at several levels, including blood pressure, endothelium, lipid metabolism and fibrinolytic system and the way they can, together with hyperinsulinism, induce atherogenesis. We review some of the therapeutic options that can reduce this state of insulin resistance as well as the morbidity and mortality associated with atherosclerosis.
在具有遗传易感性的个体中，西方生活方式有利于胰岛素抵抗状态的发展。在这种状态下，需要更高水平的胰岛素才能获得反应，从而导致高胰岛素血症。胰岛素有多个靶组织，因此胰岛素抵抗与体内多种组织、器官和系统的功能障碍（X综合征）相关。所有这些功能障碍与高胰岛素血症一起，会大大增加动脉粥样硬化性血管疾病的风险。在本文中，我们回顾了多个层面的功能障碍，包括血压、内皮、脂质代谢和纤溶系统，以及它们与高胰岛素血症一起如何诱发动脉粥样硬化。我们还回顾了一些可以减轻这种胰岛素抵抗状态以及与动脉粥样硬化相关的发病率和死亡率的治疗选择。
