Roseboom T J, van der Meulen J H, Ravelli A C, Bleker O P
Academisch Medisch Centrum, Meibergdreef 9, 1105 AZ Amsterdam.
Ned Tijdschr Geneeskd. 2000 Dec 23;144(52):2488-91.
The 'foetal origins' hypothesis (Barker hypothesis) proposes that undernutrition of the foetus during critical periods of development increases the risk of coronary heart disease in later life. The Dutch famine caused by the second World War in the winter of 1944--although a historical disaster--provides a unique opportunity to study effects of undernutrition during gestation in humans. The health of people born around the time of the Dutch famine, in the Wilhelmina Gasthuis in Amsterdam, of whom detailed birth records exist, was assessed. There were indications that chronic diseases in later life are associated with prenatal undernutrition. The associations with undernutrition, however, depend upon the time of occurrence during gestation. Our findings are compatible with the conclusion that maternal malnutrition during gestation may permanently affect adult health without affecting the size of the baby at birth. This may imply that adaptations that enable the foetus to continue to grow may have adverse consequences for health in later life.
“胎儿起源”假说（巴克假说）提出，胎儿在发育关键期的营养不足会增加其成年后患冠心病的风险。1944年冬第二次世界大战期间造成的荷兰饥荒——尽管是一场历史灾难——却提供了一个研究人类孕期营养不足影响的独特机会。对出生于荷兰饥荒时期、在阿姆斯特丹的威廉明娜医院并有详细出生记录的人的健康状况进行了评估。有迹象表明，成年后的慢性病与产前营养不足有关。然而，与营养不足的关联取决于孕期发生的时间。我们的研究结果与以下结论相符：孕期母亲营养不良可能会永久性地影响成年人健康，而不会影响出生时婴儿的大小。这可能意味着，使胎儿能够继续生长的适应性变化可能会对其成年后的健康产生不利影响。
