Hamamoto Y, Takahashi H, Matsunaga T, Murakami R, Kawahito Y, Tokuno T, Makiguchi Y, Imai K
First Department of Internal Medicine, Sapporo Medical University School of Medicine.
Nihon Rinsho Meneki Gakkai Kaishi. 1998 Dec;21(5):213-9. doi: 10.2177/jsci.21.213.
A 20-year-old woman initially presented with edematous erythema in the upper eyelids in December 1995. She was admitted to our department in January 1996 because of fever and multiple arthralgia. She was given a diagnosis of dermatomyositis (DM) on the basis of characteristic eruption, elevated serum level of creatine kinase, and increased inflammatory reaction. Chest computed tomography (CT) revealed faint interstitial changes in the left lower lung. The administration of corticosteroid caused improvement in the patient's condition and the interstitial lesion in the lung. Although she was asymptomatic, chest CT showed pneumomediastinum in the pretracheal space and concomitant pneumothorax around left bronchus. Those changes spontaneously disappeared 4 weeks later without treatment. The occurrence of pneumomediastinum in patients with DM has been well documented as an indicator of poor prognosis in the literature. It seems that a severe pulmonary disorder could secondary cause pneumomediastinum. In our case, however, the pneumomediastinum developed in spite of the low grade severity of the pulmonary lesion. This finding suggested that the pneumomediastinum may be associated with the development of DM itself.
一名20岁女性于1995年12月首次出现上眼睑水肿性红斑。1996年1月因发热和多关节痛入住我科。根据特征性皮疹、血清肌酸激酶水平升高及炎症反应增强,诊断为皮肌炎(DM)。胸部计算机断层扫描(CT)显示左下肺有轻微间质改变。给予皮质类固醇治疗后,患者病情及肺部间质病变有所改善。尽管她无症状,但胸部CT显示气管前间隙有纵隔气肿,左支气管周围伴有气胸。4周后,这些改变未经治疗自行消失。DM患者发生纵隔气肿在文献中已被充分记录为预后不良的指标。似乎严重的肺部疾病可能继发引起纵隔气肿。然而,在我们的病例中,尽管肺部病变程度较轻,仍发生了纵隔气肿。这一发现提示纵隔气肿可能与DM本身的发展有关。