Torbati I D, Harel D, Lavy S
Aviat Space Environ Med. 1975 Mar;46(3):241-3.
The excitability of the cortex in adrenalectomized and normal adult male rats to High Oxygen Pressure (HOP) was studied 2, 3, 4, 6, 8, 12 and 22 d after bilateral adrenalectomy and implantation of cerebral electrodes. Continuous electroencephalographic (EEG) recordings were obtained until the appearance of the first paroxysmal electrical discharges, which was considered to be the first indicator of the toxic effects of hyperbaric oxygen. A statistically significant change in excitability of the cortex to oxygen toxicity from 2 to 22 d following adrenalectomy was shown. Comparison of the sensitivity of the normal and adrenalectomized rats to HOP 2 d after the operation showed significant resistance of adrenalectomized rats at this time. This resistance disappeared gradually, when compared with normal rats, and cortical susceptibility increased significantly 22 d after adrenalectomy. The possible disturbances responsible for the changes in excitability of the cortex to HOP in adrenalectomized rats are discussed.
在双侧肾上腺切除并植入脑电极后的第2、3、4、6、8、12和22天，研究了成年雄性去肾上腺大鼠和正常成年雄性大鼠的皮质对高氧压（HOP）的兴奋性。持续进行脑电图（EEG）记录，直到出现首次阵发性放电，这被认为是高压氧毒性作用的首个指标。结果显示，肾上腺切除后第2天至第22天，皮质对氧毒性的兴奋性发生了统计学上的显著变化。术后第2天对正常大鼠和去肾上腺大鼠对HOP的敏感性进行比较，结果显示此时去肾上腺大鼠具有显著的抵抗力。与正常大鼠相比，这种抵抗力逐渐消失，肾上腺切除后22天皮质敏感性显著增加。文中讨论了去肾上腺大鼠皮质对HOP兴奋性变化可能涉及的干扰因素。
