Torbati D, Simon A J, Ranade A
Aviat Space Environ Med. 1981 Oct;52(10):598-603.
The EEG of rats exposed to hyperbaric oxygenation (HBO) displays electrical discharges prior to the onset of generalized clinical convulsions (GCC). The characteristics of preconvulsive electrocorticogram (ECoG) in awake, unrestrained rats exposed to 3, 4, and 5 ATA O2 were determined. The ECoG was continuously monitored and analyzed by a hybrid analog-digital system until GCC developed. The time integral of rectified voltage of the individual delta (0.5-4 c/s), theta (4-8 c/s), alpha (8-13 c/s) beta 1 (13-20 c/s), and beta 2 (20-30 c/s) bands were plotted vs. time. An elevation in delta and a temporary reduction in alpha activity before the onset of the first electrical discharge (FED) was observed. There was a continuous reduction in beta 1 and beta 2 frequency bands during the entire pre-electrical discharge period. The activity of theta, and alpha frequency bands was significantly elevated only about 1 min before the onset of the FED, and of beta 1 and beta 2 during appearance of the FED. The possible relationship between the occurrence of preconvulsive EEG changes and pathological effects of hyperbaric oxygenation is discussed.
暴露于高压氧（HBO）的大鼠脑电图在全身性临床惊厥（GCC）发作前显示出放电现象。确定了暴露于3、4和5个绝对大气压氧气的清醒、不受束缚大鼠惊厥前皮质电图（ECoG）的特征。通过混合模拟 - 数字系统持续监测和分析ECoG，直至出现GCC。绘制了各个δ（0.5 - 4赫兹）、θ（4 - 8赫兹）、α（8 - 13赫兹）、β1（13 - 20赫兹）和β2（20 - 30赫兹）频段的整流电压时间积分与时间的关系图。在首次放电（FED）开始前观察到δ频段升高以及α活动暂时降低。在整个放电前阶段，β1和β2频段持续降低。仅在FED开始前约1分钟，θ和α频段的活动显著升高，而在FED出现期间β1和β2频段活动显著升高。讨论了惊厥前脑电图变化的发生与高压氧病理效应之间的可能关系。
