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[男性生殖器官的致畸损害]

[Teratogenic damages of the male genital organs].

作者信息

Krause W

出版信息

Fortschr Med. 1976 Oct 21;94(30):1673-5.

PMID:11158
Abstract
  1. Malformations and functional disturbances of the male genitalia may be caused by teratogens. 2. A short review of the prenatal development points out the possible sites of action. 3. In animals some distinct teratogens produce typical malformation syndromo spermatogenetic cells. Cyproteronacetat, an antiandrogen, suppresses the development of the accessoric genital organs and produces an external feminisation. 4. In man, cryptorchidism, agenesis of the spermatic tracts, anorchia and hypospady are known as non-hereditary malformations. 5. The teratogenic etiology of some disturbances of the spermatogenesis is discussed.
摘要
  1. 男性生殖器的畸形和功能障碍可能由致畸剂引起。2. 对产前发育的简短回顾指出了可能的作用部位。3. 在动物中,一些特定的致畸剂会产生典型的精子发生细胞畸形综合征。抗雄激素环丙孕酮醋酸酯会抑制附属生殖器官的发育并导致外部女性化。4. 在人类中,隐睾症、精索发育不全、无睾症和尿道下裂被认为是非遗传性畸形。5. 讨论了精子发生某些障碍的致畸病因。

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1
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Fortschr Med. 1976 Oct 21;94(30):1673-5.
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The male genital tract and the nipples of male and female offspring of rats given the non-steroidal antiandrogens DIMP and Sch 13521, during pregnancy.在孕期给予大鼠非甾体类抗雄激素DIMP和Sch 13521后,其雄性后代的生殖道以及雄性和雌性后代的乳头情况。
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