Bleiberg I, Perah G
Blood. 1975 Apr;45(4):511-5.
The development of erythroid colonies of fetal liver hemopoietic cell origin in adult irradiated polycythemic mice was studied. It was found that orchidectomy sharply reduced the number of erythroid colonies developed in the spleen of these polycythemic male recipients. Estrogen injection to the orchidectomized polycythemic recipient did not further decrease the number of erythroid colonies developed. It is concluded that the development of erythroid colonies of fetal liver origin in polycythemic male recipients is maintained mainly by testicular testosterone. The complete suppression of these colonies in female recipients does not seem to be a result of inhibition by estrogen.
研究了成年受辐照的真性红细胞增多症小鼠中胎儿肝脏造血细胞来源的红系集落的发育情况。发现去势显著减少了这些真性红细胞增多症雄性受体脾脏中发育的红系集落数量。对去势的真性红细胞增多症受体注射雌激素并没有进一步减少所发育的红系集落数量。得出的结论是，真性红细胞增多症雄性受体中胎儿肝脏来源的红系集落的发育主要由睾丸睾酮维持。雌性受体中这些集落的完全抑制似乎不是雌激素抑制的结果。
