Cañero E, Cabrera C, Makarychev V A, Gribanovskii I B, Morlans J
Bull Exp Biol Med. 1975 Jan;77(7):737-40. doi: 10.1007/BF00799304.
Atrial arrhythmias were induced in experiments on dogs by electrical stimulation or by local application of aconitine and methacholine to the atrium. The action of the defibrillator discharge on these arrhythmias was studied. The defibrillator discharge abolished the arrhythmias maintained by the circus movement of the excitation wave over the atria but did not abolish sinus tachycardia or ectopic aconitine tachysystoles. The threshold of the defibrillating effect depends on the existence of micro-or macro-reentries. Thmechanism of defibrillation consists of excitation of the atrial myocardium with a consequent decrease in the pathway for the circulation of excitation to below the critical size for maintaining the circus movement of the excitation wave. The axtion of the defibrillator does not inihibit the automatism of the nomotopic and heterotopic cardiac pacemakers.
在犬实验中，通过电刺激或向心房局部应用乌头碱和乙酰甲胆碱诱发房性心律失常。研究了除颤器放电对这些心律失常的作用。除颤器放电消除了由兴奋波在心房上的环形运动维持的心律失常，但未消除窦性心动过速或异位乌头碱性心动过速。除颤效应的阈值取决于微折返或宏折返的存在。除颤机制包括激发心房心肌，从而使兴奋循环途径减小至低于维持兴奋波环形运动的临界大小。除颤器的作用并不抑制正常和异位心脏起搏器的自律性。
