Effects of single oral doses of gemifloxacin (320 milligrams) versus trovafloxacin (200 milligrams) on fecal flora in healthy volunteers.
作者信息
Garcia-Calvo G, Molleja A, Giménez M J, Parra A, Nieto E, Ponte C, Aguilar L, Soriano F
机构信息
Department of Medical Microbiology, Fundación Jiménez Díaz, Madrid, Spain.
出版信息
Antimicrob Agents Chemother. 2001 Feb;45(2):608-11. doi: 10.1128/AAC.45.2.608-611.2001.
Abstract
Gemifloxacin and trovafloxacin were administered to 12 volunteers in a randomized crossover trial with a 2-week washout period. Stool samples were collected predose and 1, 2, and 3 days postdose. Both quinolones reduced the number of organisms of the family Enterobacteriaceae and aerobic gram-positive organisms. Escherichia coli reduction was greater with gemifloxacin than with trovafloxacin, with postdose isolation of quinolone-resistant strains for which MICs of trovafloxacin were higher than those of gemifloxacin.
摘要
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