Comparison of rufloxacin and norfloxacin effects on faecal flora.
作者信息
Marco F, Giménez M J, Jiménez de Anta M T, Marcos M A, Salvá P, Aguilar L
机构信息
Microbiology Department, Hospital Clinic i Provincial, Barcelona, Spain.
出版信息
J Antimicrob Chemother. 1995 Jun;35(6):895-901. doi: 10.1093/jac/35.6.895.
PMID:7559202
Abstract
The suppression of faecal Escherichia coli by quinolones was studied in a randomized cross-over phase I trial with single oral doses of 400 mg rufloxacin or norfloxacin. Both drugs caused > 70% decontamination in a similar number of subjects in the 72 h post-dose period (83% vs 100% respectively), but suppression of E. coli at 168 h was significantly (P < 0.05) higher after rufloxacin (83.3 vs 40%).
摘要
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