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丝裂霉素C辅助小梁切除术治疗外伤性房角后退性青光眼

Trabeculectomy with mitomycin C in the treatment of post-traumatic angle recession glaucoma.

作者信息

Manners T, Salmon J F, Barron A, Willies C, Murray A D

机构信息

Department of Ophthalmology, Groote Schuur Hospital, Cape Town, South Africa.

出版信息

Br J Ophthalmol. 2001 Feb;85(2):159-63. doi: 10.1136/bjo.85.2.159.

Abstract

AIM

The presence of traumatic angle recession is a risk factor for failure of glaucoma filtration surgery and a previous study has suggested that antimetabolite treatment should be used in these patients. This study was undertaken to determine for the first time the mid term results of trabeculectomy with intraoperative application of mitomycin C in patients with post-traumatic angle recession glaucoma.

METHODS

A retrospective analysis was made of 43 consecutive trabeculectomy procedures in 41 young black/mixed race patients followed for a mean period of 25 months (range 2-66 months). Mitomycin C 0.02% was applied between the sclera and conjunctiva for 1-5 minutes at the time of surgery. The intraocular pressure and visual acuity were measured postoperatively. The success of this technique was analysed by using a Kaplan-Meier cumulative survival curve.

RESULTS

The intraocular pressure was successfully controlled at last follow up without topical treatment in 77% (33/43 eyes) and the visual acuity was the same or better in 81% (35/43 eyes). Cumulative probability of success was 85% at 1 year follow up, 81% at 2 years, and 66% at 3 years and thereafter. Hypotonous maculopathy occurred in one patient and no cases of late bleb infection were found.

CONCLUSIONS

In medically uncontrolled post-traumatic angle recession glaucoma trabeculectomy with mitomycin C is an effective surgical procedure with an acceptable complication rate. Good intraocular pressure control and preservation of vision can be expected in most patients.

摘要

目的

外伤性房角后退是青光眼滤过性手术失败的一个危险因素,先前的一项研究表明,这些患者应使用抗代谢药物治疗。本研究首次对创伤性房角后退性青光眼患者术中应用丝裂霉素C进行小梁切除术的中期结果进行了评估。

方法

对41例年轻黑种人/混血患者连续进行的43例小梁切除术进行回顾性分析,平均随访25个月(2 - 66个月)。手术时在巩膜和结膜之间应用0.02%的丝裂霉素C 1 - 5分钟。术后测量眼压和视力。采用Kaplan-Meier累积生存曲线分析该技术的成功率。

结果

在最后一次随访时,77%(33/43眼)的患者眼压在未使用局部治疗的情况下得到成功控制,81%(35/43眼)的患者视力保持不变或提高。随访1年时成功率的累积概率为85%,2年时为81%,3年及以后为66%。1例患者发生低眼压性黄斑病变,未发现晚期滤过泡感染病例。

结论

对于药物治疗无法控制的创伤性房角后退性青光眼,小梁切除术联合丝裂霉素C是一种有效的手术方法,并发症发生率可接受。大多数患者有望实现良好的眼压控制和视力保留。

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