Butson A R
Can J Surg. 1975 Mar;18(2):145-8.
Observations on wounds sustained at subfreezing temperatures in husky dogs and in man suggested that exposed wet tissues readily become frozen. Frostbite of wounds caused tissue necrosis, wound sepsis and delayed healing, but immediate wound suture protected against this sequence. To explore the effect of wound closure on healing frostbitten tissue, healing of paired dorsal wounds was studied in 20 rats. In each animal one wound was sutured and the other was left open. In 10 animals both wounds were frozen with Dry Ice. All sutured wounds healed primarily. Most of the control open wounds had healed at 15 days, but in the frozen wounds healing was delayed and infection ensued. It is suggested that at temperatures much below freezing the immediate treatment of a wound should include prevention of frostbite by wound closure.
对哈士奇犬和人类在冰点以下温度下所受伤口的观察表明，暴露的湿润组织很容易结冰。伤口冻伤会导致组织坏死、伤口感染和愈合延迟，但立即进行伤口缝合可防止出现这种情况。为了探究伤口闭合对冻伤组织愈合的影响，在20只大鼠身上研究了成对背部伤口的愈合情况。在每只动物身上，一个伤口进行缝合，另一个伤口保持开放。在10只动物中，两个伤口均用干冰冷冻。所有缝合的伤口均一期愈合。大多数对照开放伤口在15天时已愈合，但冷冻伤口的愈合延迟且发生了感染。有人提出，在远低于冰点的温度下，伤口的即时处理应包括通过伤口闭合来预防冻伤。
