爱泼斯坦-巴尔病毒核蛋白2至少有两个介导自身缔合的N端结构域。
Epstein-Barr virus nuclear protein 2 has at least two N-terminal domains that mediate self-association.
作者信息
Harada S, Yalamanchili R, Kieff E
机构信息
Program in Virology and Department of Medicine, Channing Laboratory, Brigham and Women's Hospital and Harvard University, Boston, Massachusetts 02115, USA.
出版信息
J Virol. 2001 Mar;75(5):2482-7. doi: 10.1128/JVI.75.5.2482-2487.2001.
Abstract
Previous genetic and biochemical analyses have indicated that the Epstein-Barr virus EBNA-2 amino terminus is important for primary B-lymphocyte growth transformation and may be involved in self-association. We now report that EBNA-2 has at least two domains, amino acids 1 to 60 and 96 to 210, which independently mediate homotypic association, 1 to 60 with 1 to 60 and 96 to 210 with 96 to 210. EBNA-2 self-association is likely to be critical to the ability of EBNA-2 to interact simultaneously with multiple cellular transcription factors, coactivators, and histone acetyltransferases through its RBPJkappa binding and acidic activating domains.
摘要
先前的遗传学和生物化学分析表明，爱泼斯坦-巴尔病毒EBNA-2氨基末端对原发性B淋巴细胞生长转化很重要，可能参与自我缔合。我们现在报告EBNA-2至少有两个结构域，即氨基酸1至60和96至210，它们分别介导同型缔合，1至60与1至60缔合，96至210与96至210缔合。EBNA-2自我缔合可能对EBNA-2通过其RBPJκ结合域和酸性激活域同时与多种细胞转录因子、共激活因子和组蛋白乙酰转移酶相互作用的能力至关重要。
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本文引用的文献
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Epstein-Barr virus nuclear protein 2 interacts with p300, CBP, and PCAF histone acetyltransferases in activation of the LMP1 promoter.爱泼斯坦-巴尔病毒核蛋白2在激活LMP1启动子时与p300、CBP和PCAF组蛋白乙酰转移酶相互作用。
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Three unrelated viral transforming proteins (vIRF, EBNA2, and E1A) induce the MYC oncogene through the interferon-responsive PRF element by using different transcription coadaptors.三种不相关的病毒转化蛋白（vIRF、EBNA2和E1A）通过使用不同的转录共激活因子，经干扰素应答性PRF元件诱导MYC癌基因。
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The proto-oncogene c-myc is a direct target gene of Epstein-Barr virus nuclear antigen 2.原癌基因c-myc是爱泼斯坦-巴尔病毒核抗原2的直接靶基因。
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An ATF/CRE element mediates both EBNA2-dependent and EBNA2-independent activation of the Epstein-Barr virus LMP1 gene promoter.一个ATF/CRE元件介导了爱泼斯坦-巴尔病毒LMP1基因启动子的EBNA2依赖性和EBNA2非依赖性激活。
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Epstein-Barr virus nuclear protein LP stimulates EBNA-2 acidic domain-mediated transcriptional activation.爱泼斯坦-巴尔病毒核蛋白LP刺激EBNA-2酸性结构域介导的转录激活。
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