药理学诱导的NMDA受体活性变化对人类长期记忆的影响。
Effects of pharmacologically induced changes in NMDA-receptor activity on long-term memory in humans.
作者信息
Rammsayer T H
机构信息
Georg Elias Mueller Institute for Psychology, University of Göttingen, D-37073 Göttingen, Germany.
出版信息
Learn Mem. 2001 Jan-Feb;8(1):20-5. doi: 10.1101/lm.33701.
Abstract
In a double-blind crossover design, either 30 mg of the noncompetitive NMDA-receptor antagonist memantine or a placebo was administered to 40 healthy male volunteers. Twenty line drawings of objects and 20 photographs of unfamiliar faces were presented on a computer screen. After a retention interval of 80 min, the participants' task was to select the original objects and faces from a set of 80 items. Results were analyzed applying a signal-detection-theory approach. Recognition performance for objects was significantly impaired under memantine as compared to placebo, whereas performance on face recognition was not affected. Findings support the notion of differential effects of NMDA-receptor antagonists on memory functions in humans.
摘要
在一项双盲交叉设计中，40名健康男性志愿者被给予30毫克非竞争性N-甲基-D-天冬氨酸（NMDA）受体拮抗剂美金刚或安慰剂。20张物体线条图和20张陌生面孔照片在电脑屏幕上呈现。在80分钟的保留间隔后，参与者的任务是从80个项目中选出原来的物体和面孔。结果采用信号检测理论方法进行分析。与安慰剂相比，服用美金刚时物体的识别性能显著受损，而面部识别性能未受影响。研究结果支持NMDA受体拮抗剂对人类记忆功能有不同影响这一观点。
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