Atherton A, Busfield D, Hellman K
Cancer Res. 1975 Apr;35(4):953-7.
Some agents that inhibit platelet aggregation, e.g., aspirin and dipyridamole, ahve been reported to prevent metastasis formation. To see whether inhibition of platelet aggregation could account for the antimetastatic action of (plus or minus)-1,2- bis(3,5-dioxopiperazin-1-yl)propane, this compound was investigated in vivo for any effects on platelet behavior and thrombogenesis. (plus or minus)-1,2-Bis(3,5-dioxopiperazin-1-yl)propane inhibited the formation of platelet thrombi in blood vessels on the surface of the rat brain and in the hamster cheek pouch. 1,2-Bis(dioxo-4-methylpiperazin-1-yl)ethane, a closely related analog of (plus or minus)-1,2-bis(3,5-dioxopiperazin-1-yl)propane, but without antimetastatic action, inhibited thrombus formation in vivo as effectively as (plus or minus)-1,2-bis(3,5-dioxopiperazin-1-yl)propane. It seems unlikely therefore that the antimetastatic action of (plus or minus)-1,2-bis(3,5-dioxopiperazine-l-yl)propane derives from its effects on thrombogenesis. Neither platelet numbers nor the ionized plasma calcium concentrations were changed after (plus or minus)-1,2-bis(3,5-dioxopiperazin-l-yl)propane administration.
据报道，一些抑制血小板聚集的药物，如阿司匹林和双嘧达莫，可预防转移灶的形成。为了探究抑制血小板聚集是否能解释（±）-1,2-双（3,5-二氧代哌嗪-1-基）丙烷的抗转移作用，对该化合物在体内对血小板行为和血栓形成的影响进行了研究。（±）-1,2-双（3,5-二氧代哌嗪-1-基）丙烷抑制大鼠脑表面血管和仓鼠颊囊内血小板血栓的形成。1,2-双（二氧代-4-甲基哌嗪-1-基）乙烷是（±）-1,2-双（3,5-二氧代哌嗪-1-基）丙烷的紧密相关类似物，但无抗转移作用，其在体内抑制血栓形成的效果与（±）-1,2-双（3,5-二氧代哌嗪-1-基）丙烷相同。因此，（±）-1,2-双（3,5-二氧代哌嗪-1-基）丙烷的抗转移作用似乎并非源于其对血栓形成的影响。给予（±）-1,2-双（3,5-二氧代哌嗪-1-基）丙烷后，血小板数量和血浆离子钙浓度均未改变。
