Miller A B, Salcedo E E, Bahler R C
Chest. 1975 Feb;67(2):230-2. doi: 10.1378/chest.67.2.230.
The association of hypoplastic thumb and atrial septal defect, (Holt-Oram syndrome) with a prolapsed mitrial valve is described. Recognition of this association adds further support to the concept that the prolapsed mitrial valve syndrome is not necessarily an isolated cardiac disorder but may be part of a more generalized heritable disorder of connective tissue.
本文描述了发育不全的拇指与房间隔缺损（霍尔-奥姆综合征）合并二尖瓣脱垂的关联。对这种关联的认识进一步支持了以下观点：二尖瓣脱垂综合征不一定是一种孤立的心脏疾病，而可能是更广泛的遗传性结缔组织疾病的一部分。
