谷氨酸受体通道特征

Glutamate receptor channel signatures.

作者信息

Sprengel R, Aronoff R, Völkner M, Schmitt B, Mosbach R, Kuner T

机构信息

Dept. of Molecular Neuroscience, Max-Planck-Institute for Medical Research, Jahnstrasse 29, D-69120, Heidelberg, Germany.

出版信息

Trends Pharmacol Sci. 2001 Jan;22(1):7-10. doi: 10.1016/s0165-6147(00)01588-1.

DOI:10.1016/s0165-6147(00)01588-1

PMID:11165660

Abstract

Genes encoding glutamate receptor channel subunits were identified in genomes from Drosophila melanogaster and Caenorhabditis elegans by homology search with amino acid sequences that participate in the conserved channel pore. The predicted sequences of the putative glutamate receptor subunits revealed a distinct channel pore signature for each receptor subtype and for most of them, related members were found in C. elegans and Drosophila.

摘要

通过与参与保守通道孔的氨基酸序列进行同源性搜索，在黑腹果蝇和秀丽隐杆线虫的基因组中鉴定出了编码谷氨酸受体通道亚基的基因。推定的谷氨酸受体亚基的预测序列显示了每种受体亚型独特的通道孔特征，并且对于其中大多数而言，在秀丽隐杆线虫和果蝇中发现了相关成员。