染色体乘客与有丝分裂的（极光激酶）ABC

Chromosomal passengers and the (aurora) ABCs of mitosis.

作者信息

Adams R R, Carmena M, Earnshaw W C

机构信息

Wellcome Centre for Cell Biology, Institute of Cell and Molecular Biology, University of Edinburgh, Michael Swann Building, King's Buildings, Mayfield Road, EH9 3JR, Edinburgh, UK.

出版信息

Trends Cell Biol. 2001 Feb;11(2):49-54. doi: 10.1016/s0962-8924(00)01880-8.

DOI:10.1016/s0962-8924(00)01880-8

PMID:11166196

Abstract

Chromosomal passengers are proteins that move from centromeres to the spindle midzone during mitosis. Recent experiments show that the passengers inner centromere protein (INCENP) and aurora-B kinase are in a macromolecular complex that might also contain a third passenger, survivin. The chromosomal passenger complex functions throughout mitosis in chromosome condensation and segregation, and at the end of mitosis, in the completion of cytokinesis.

摘要

染色体乘客蛋白是在有丝分裂过程中从着丝粒移动到纺锤体中间区的蛋白质。最近的实验表明，乘客蛋白内着丝粒蛋白（INCENP）和极光B激酶存在于一个大分子复合物中，该复合物可能还包含第三种乘客蛋白——生存素。染色体乘客复合物在有丝分裂的整个过程中参与染色体浓缩和分离，并在有丝分裂末期参与胞质分裂的完成。