兴奋性代谢型谷氨酸受体1和代谢型谷氨酸受体5在纹状体胆碱能中间神经元上的功能性共表达。
Functional coexpression of excitatory mGluR1 and mGluR5 on striatal cholinergic interneurons.
作者信息
Pisani A, Bonsi P, Centonze D, Bernardi G, Calabresi P
机构信息
Clinica Neurologica, Dipartimento di Neuroscienze, Università di Roma "Tor Vergata", Rome, Italy.
出版信息
Neuropharmacology. 2001 Mar;40(3):460-3. doi: 10.1016/s0028-3908(00)00184-2.
The group I mGluR agonist (S)-3,5-dihydroxyphenylglycine (3,5-DHPG) and the mGluR5 agonist 2-chloro-5-hydroxyphenylglycine both induced a membrane depolarisation of striatal cholinergic interneurons. The response to 3,5-DHPG was blocked only by the coadministration of mGluR1 and mGluR5 antagonists, suggesting that both mGluRs are involved in this excitatory effect in striatal cholinergic interneurons.
I 型代谢型谷氨酸受体激动剂（S）-3,5-二羟基苯甘氨酸（3,5-DHPG）和代谢型谷氨酸受体 5 激动剂 2-氯-5-羟基苯甘氨酸均能诱导纹状体胆碱能中间神经元发生膜去极化。对 3,5-DHPG 的反应仅在同时给予代谢型谷氨酸受体 1 和代谢型谷氨酸受体 5 拮抗剂时被阻断，这表明两种代谢型谷氨酸受体均参与了纹状体胆碱能中间神经元的这种兴奋作用。
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