Suppr超能文献

斑马鱼的fth1、slc3a2、men1、pc、fgf3和cycd1基因定义了7号连锁群与人类11号染色体q13区域之间两个保守的同线性区域。

The zebrafish fth1, slc3a2, men1, pc, fgf3 and cycd1 genes define two regions of conserved synteny between linkage group 7 and human chromosome 11q13.

作者信息

Yoder J A, Litman G W

机构信息

Children's Research Institute, University of South Florida College of Medicine/All Children's Hospital, Department of Pediatrics, 140 Seventh Avenue South, FL 33701, St. Petersburg, USA.

出版信息

Gene. 2000 Dec 31;261(2):235-42. doi: 10.1016/s0378-1119(00)00503-5.

Abstract

In addition to being an excellent model system for studying vertebrate development, the zebrafish has become a great tool for gene discovery by mutational analysis. The recent availability of the zebrafish EST database and radiation hybrid mapping panels has dramatically expanded the framework for genomic research in this species. Developing comparative maps of the zebrafish and human genomes is of particular importance for zebrafish mutagenesis studies in which human orthologs are sought for zebrafish genes. However, only partial cDNA sequences are determined routinely for mapped ESTs, leaving the identity of the EST in question. It previously had been reported that zebrafish linkage group 7 shares conserved synteny with human chromosome 11q13. In an effort to further define this relationship, five full-length zebrafish cDNAs, fth1, slc3a2, prkri, cd81, and pc, as well as one putative human gene, DBX were identified and their map positions ascertained. These six genes, along with men1, fgf3 and cycd1 define two regions of conserved synteny between linkage group 7 and 11q13.

摘要

斑马鱼不仅是研究脊椎动物发育的优秀模型系统,还通过突变分析成为基因发现的重要工具。斑马鱼EST数据库和辐射杂种图谱板的出现极大地扩展了该物种基因组研究的框架。绘制斑马鱼和人类基因组的比较图谱对于在斑马鱼诱变研究中寻找人类直系同源基因尤为重要。然而,常规确定的已定位ESTs只有部分cDNA序列,这使得所讨论的EST的身份不明确。此前有报道称斑马鱼连锁群7与人类染色体11q13具有保守的同线性。为了进一步明确这种关系,鉴定了五个全长斑马鱼cDNA,即fth1、slc3a2、prkri、cd81和pc,以及一个推定的人类基因DBX,并确定了它们的图谱位置。这六个基因与men1、fgf3和cycd1一起定义了连锁群7和11q13之间保守同线性的两个区域。

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验