Platten M, Wick W, Weller M
Department of Neurology, University of Tübingen, 72076 Tübingen, Germany.
Microsc Res Tech. 2001 Feb 15;52(4):401-10. doi: 10.1002/1097-0029(20010215)52:4<401::AID-JEMT1025>3.0.CO;2-C.
Characteristics of human malignant glioma are excessive proliferation, infiltrative growth, angiogenesis and suppression of anti-tumor immune surveillance. Transforming growth factor-beta (TGF-beta), a versatile cytokine, is intimately involved in the regulation of these processes. Here, we discuss the interactions of TGF-beta with growth factors, such as basic fibroblast growth factor (bFGF), epidermal growth factor (EGF) and platelet derived growth factor (PDGF), metalloproteinases (MMP-2, MMP-9) and their inhibitor, plasmin activator inhibitor-1 (PAI-1), and immune cells, like natural killer cells, T-cells and microglia. The differential effects of TGF-beta in glioma biology are outlined with emphasis on the induction of a survival advantage for glioma cells by enforced cell growth, migration, invasion, angiogenesis and immune paralysis. By virtue of its growth regulatory and immunomodulatory properties, TGF-beta promises to become a novel target for the experimental therapy of human malignant glioma.
人类恶性胶质瘤的特征是过度增殖、浸润性生长、血管生成以及抗肿瘤免疫监视的抑制。转化生长因子-β（TGF-β）是一种多功能细胞因子，密切参与这些过程的调控。在此，我们讨论TGF-β与生长因子（如碱性成纤维细胞生长因子（bFGF）、表皮生长因子（EGF）和血小板衍生生长因子（PDGF））、金属蛋白酶（MMP-2、MMP-9）及其抑制剂纤溶酶激活物抑制剂-1（PAI-1）以及免疫细胞（如自然杀伤细胞、T细胞和小胶质细胞）之间的相互作用。概述了TGF-β在胶质瘤生物学中的不同作用，重点强调了通过促进细胞生长、迁移、侵袭、血管生成和免疫麻痹为胶质瘤细胞诱导生存优势。凭借其生长调节和免疫调节特性，TGF-β有望成为人类恶性胶质瘤实验治疗的新靶点。
