包膜糖蛋白在人类免疫缺陷病毒感染中T辅助细胞耗竭中的作用

The Role of the Envelope Glycoprotein in the Depletion of T Helper Cells in Human Immunodeficiency Virus Infection.

作者信息

Jassoy Christian, Heinkelein Martin, Sopper Sieghart

机构信息

Julius-Maximilians University, Institute for Virology and Immunobiology, Würzburg, Germany.

出版信息

Pathol Oncol Res. 1997;3(1):62-67. doi: 10.1007/BF02893356.

DOI:10.1007/BF02893356

PMID:11173628

Abstract

Infection with the human immunodeficiency virus (HIV) causes gradual depletion of CD4+ T helper lymphocytes and destruction of the lymphoid tissue, which ultimately leads to a fatal defect of the cellular immune system. Paramount to the understanding of the pathogenesis of HIV infection is to elucidate the mechanism which underlies the loss of T helper cells. Various ideas have been proposed in order to explain this issue. Several hypotheses have focused on the role of the envelope glycoprotein in this process. This review summarizes the data obtained and concepts proposed regarding the involvement of the HIV glycoprotein in the pathology of CD4+ T cell depletion.

摘要

感染人类免疫缺陷病毒（HIV）会导致CD4 +辅助性T淋巴细胞逐渐耗竭以及淋巴组织破坏，最终导致细胞免疫系统出现致命缺陷。理解HIV感染发病机制的关键在于阐明T辅助细胞丧失的潜在机制。为了解释这个问题，人们提出了各种观点。有几种假说聚焦于包膜糖蛋白在此过程中的作用。本综述总结了关于HIV糖蛋白参与CD4 + T细胞耗竭病理过程所获得的数据和提出的概念。