吉米沙星对德国肺炎链球菌分离株的体外活性

In vitro activity of gemifloxacin against Streptococcus pneumoniae isolates in Germany.

作者信息

Lemmen S, Al-Lahham A, Lütticken R, Reinert R R

机构信息

Institute of Medical Microbiology, University Hospital (RWTH) Aachen, National Reference Center for Streptococci, Pauwelstrasse 30, D-52057 Aachen, Germany.

出版信息

Chemotherapy. 2001 Mar-Apr;47(2):104-9. doi: 10.1159/000048508.

DOI:10.1159/000048508

PMID:11173811

Abstract

The MICs (minimal inhibitory concentrations) of gemifloxacin, moxifloxacin, ofloxacin, ciprofloxacin, levofloxacin, sparfloxacin, penicillin G, tetracycline and erythromycin were determined for 200 clinical pneumococcal isolates using the microbroth dilution method. MIC(50) and MIC(90) values were as follows (mg/l): 0.016 and 0.016 (gemifloxacin, penicillin-intermediate strains), 0.03 and 0.06 (gemifloxacin, penicillin-susceptible strains); 0.125-0.5 and 0.25 (moxifloxcacin); 1-2 and 4 (ciprofloxacin and ofloxacin); 1 and 2 (levofloxacin), and 0.25-0.5 and 0.5 (sparfloxacin). MIC(50) and MIC(90) values for the fluoroquinolones were nearly identical for individual antimicrobial agents in the penicillin-susceptible and penicillin-intermediate groups of strains. Erythromycin and tetracycline were less active against penicillin-intermediate pneumococci isolates (erythromycin: MIC(90) 8 mg/l; MIC range 0.06-> or =64 mg/l; tetracycline: MIC(90) > or =64 mg/l, MIC range 0.25- > or =64 mg/l) as compared to penicillin-susceptible isolates (erythromycin: MIC(90) 0.5 mg/l, MIC range 0.06-> or =64 mg/l; tetracycline: MIC(90) 8 mg/l, MIC range 0.06-> or =64 mg/l).

摘要

采用微量肉汤稀释法测定了200株临床肺炎球菌分离株对吉米沙星、莫西沙星、氧氟沙星、环丙沙星、左氧氟沙星、司帕沙星、青霉素G、四环素和红霉素的最低抑菌浓度（MIC）。MIC50和MIC90值如下（mg/l）：0.016和0.016（吉米沙星，青霉素中介菌株），0.03和0.06（吉米沙星，青霉素敏感菌株）；0.125 - 0.5和0.25（莫西沙星）；1 - 2和4（环丙沙星和氧氟沙星）；1和2（左氧氟沙星），以及0.25 - 0.5和0.5（司帕沙星）。对于青霉素敏感和青霉素中介菌株组中的各个抗菌药物，氟喹诺酮类药物的MIC50和MIC90值几乎相同。与青霉素敏感分离株（红霉素：MIC90 0.5 mg/l，MIC范围0.06 -> 或 = 64 mg/l；四环素：MIC90 8 mg/l，MIC范围0.06 -> 或 = 64 mg/l）相比，红霉素和四环素对青霉素中介肺炎球菌分离株的活性较低（红霉素：MIC90 8 mg/l；MIC范围0.06 -> 或 = 64 mg/l；四环素：MIC90 > 或 = 64 mg/l，MIC范围0.25 -> 或 = 64 mg/l）。