Kerawala M, Ambler J E, Lee P Y, Drabu Y J
Department of Microbiology, North Middlesex Hospital NHS Trust, London, UK.
Eur J Clin Microbiol Infect Dis. 2001 Apr;20(4):271-5. doi: 10.1007/pl00011264.
The purpose of the study presented here was to determine the in vitro activity of gemifloxacin compared with that of 11 other antimicrobial agents (5 of them quinolones) against 400 isolates of beta-haemolytic and viridans group streptococci. The minimum inhibitory concentration values for gemifloxacin against 90% of the streptococci tested were as follows: Lancefield groups A, C and G, 0.06 microg/ml; Lancefield group B, Streptococcus mitis, Streptococcus mutans and Streptococcus bovis, 0.125 microg/ml; and Streptococcus milleri, 0.03 microg/ml. Resistance to penicillin, ampicillin and erythromycin was found mainly in the Streptococcus mitis isolates; tetracycline showed variable results, and no vancomycin resistance was encountered. Higher rates of ciprofloxacin resistance were identified in the Streptococcus bovis, mitis and mutans isolates. In conclusion, gemifloxacin was the most active quinolone tested followed by trovafloxacin, sparfloxacin, grepafloxacin, ciprofloxacin and levofloxacin, especially against isolates resistant to beta-lactam agents, macrolides and tetracycline.
本研究的目的是确定吉米沙星与其他11种抗菌药物（其中5种为喹诺酮类）相比，对400株β-溶血性链球菌和草绿色链球菌的体外活性。吉米沙星对90%受试链球菌的最低抑菌浓度值如下：兰斯菲尔德A、C和G组，0.06微克/毫升；兰斯菲尔德B组、缓症链球菌、变形链球菌和牛链球菌，0.125微克/毫升；米勒链球菌，0.03微克/毫升。对青霉素、氨苄西林和红霉素的耐药性主要见于缓症链球菌分离株；四环素结果不一，未发现对万古霉素耐药的情况。在牛链球菌、缓症链球菌和变形链球菌分离株中发现较高的环丙沙星耐药率。总之，吉米沙星是受试喹诺酮类药物中活性最强的，其次是曲伐沙星、司帕沙星、格帕沙星、环丙沙星和左氧氟沙星，尤其对耐β-内酰胺类药物、大环内酯类药物和四环素的分离株。
