脊索前中胚层在神经模式形成中的作用。
The role of prechordal mesendoderm in neural patterning.
作者信息
Kiecker C, Niehrs C
机构信息
Division of Molecular Embryology, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.
出版信息
Curr Opin Neurobiol. 2001 Feb;11(1):27-33. doi: 10.1016/s0959-4388(00)00170-7.
Prechordal mesendoderm is formed in response to Nodal and maternal beta-Catenin signaling and is regulated by signals from anterior endoderm and chordamesoderm. Prechordal mesendodermal cells are involved in neural induction and in anteroposterior and dorsoventral neural patterning. Inhibitors of Wnt and BMP growth factors secreted by prechordal mesendoderm mediate neural induction and anteroposterior and dorsoventral patterning, whereas SHH and TGF betas mediate dorsoventral patterning.
前索中胚层是在Nodal和母体β-连环蛋白信号的作用下形成的，并受来自前肠内胚层和脊中胚层信号的调节。前索中胚层细胞参与神经诱导以及前后和背腹神经模式形成。前索中胚层分泌的Wnt和BMP生长因子抑制剂介导神经诱导以及前后和背腹模式形成，而SHH和转化生长因子β介导背腹模式形成。
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