[以对抗雌激素的反应作为子宫内膜癌激素敏感性的标准]
[Response to an antiestrogen as a criterion for hormonal sensitivity of endometrial cancer].
作者信息
Robel P, Lévy C, Wolff J P, Nicolas J C, Baulieu E E
出版信息
C R Acad Hebd Seances Acad Sci D. 1978 Nov 27;287(15):1353-6.
PMID:111815
Abstract
A test is described for the evaluation of hormone sensitivity of endometrial cancer in vivo. The concentrations of progesterone and estradiol receptors, and the activities of ornithine-decarboxylase and 17 beta-hydroxysteroid oxido-reductase enzymes have been measured in the tumor, before and after administration of the anti-estrogen tamoxifen. The responses observed, in particular the increase of progesterone receptor, could allow a more rational approach to hormonal therapy of endometrial cancer.
摘要
本文描述了一种用于评估体内子宫内膜癌激素敏感性的试验。在给予抗雌激素他莫昔芬之前和之后，已测量了肿瘤中孕酮和雌二醇受体的浓度，以及鸟氨酸脱羧酶和17β-羟基类固醇氧化还原酶的活性。观察到的反应，特别是孕酮受体的增加，可能为子宫内膜癌的激素治疗提供更合理的方法。
相似文献
1
[Response to an antiestrogen as a criterion for hormonal sensitivity of endometrial cancer].[以对抗雌激素的反应作为子宫内膜癌激素敏感性的标准]
C R Acad Hebd Seances Acad Sci D. 1978 Nov 27;287(15):1353-6.
2
Female sex steroid receptors in postmenopausal endometrial carcinoma and biochemical response to an antiestrogen.
Cancer Res. 1981 Mar;41(3):1140-7.
3
Hormonal and receptor status in postmenopausal women with endometrial carcinoma before and after treatment with tamoxifen.
Tumori. 1984 Apr 30;70(2):189-92. doi: 10.1177/030089168407000214.
4
Tamoxifen and endometrial carcinoma: alterations in estrogen and progesterone receptors in untreated patients and combination hormonal therapy in advanced neoplasia.他莫昔芬与子宫内膜癌：未治疗患者雌激素和孕激素受体的改变以及晚期肿瘤的联合激素治疗
Am J Obstet Gynecol. 1984 May 15;149(2):149-53. doi: 10.1016/0002-9378(84)90187-x.
5
Hormone receptors in endometrial cancer.
Cancer. 1981 Jul 15;48(2 Suppl):638-41. doi: 10.1002/1097-0142(19810715)48:1+<638::aid-cncr2820481331>3.0.co;2-1.
6
7
The endometrial adenocarcinoma as a model for hormone-dependency and hormone-responsiveness of gynaecological cancers.
Eur J Obstet Gynecol Reprod Biol. 1984 Dec;18(5-6):335-41. doi: 10.1016/0028-2243(84)90055-8.
8
Identification of endocrine responsive breast and endometrial carcinoma using steroid hormone receptors.利用类固醇激素受体鉴定内分泌反应性乳腺癌和子宫内膜癌。
Prog Clin Biol Res. 1988;276:11-41.
9
Hormonal aspects of endometrial cancer.
Curr Opin Obstet Gynecol. 1990 Feb;2(1):69-73.
10
A dynamic test of hormonal sensitivity of gynecologic malignancy by use of an antiestrogen, tamoxifen.使用抗雌激素药物他莫昔芬对妇科恶性肿瘤进行激素敏感性动态测试。
Am J Obstet Gynecol. 1988 May;158(5):1120-3. doi: 10.1016/0002-9378(88)90234-7.
引用本文的文献
1
Metabolites of tamoxifen in animals and man: identification, pharmacology, and significance.他莫昔芬在动物和人体内的代谢产物：鉴定、药理学及意义
Breast Cancer Res Treat. 1982;2(2):123-38. doi: 10.1007/BF01806449.
Zotero 插件