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瘤内注射卡介苗、静脉注射免疫淋巴细胞以及用神经氨酸酶处理的肿瘤细胞进行免疫治疗黑色素瘤;一项临床评估。

Intralesional BCG, intravenous immune lymphocytes, and immunization with neuraminidase-treated tumor cells to manage melanoma; A clinical assessment.

作者信息

Seigler H F, Shingleton W W, Pickrell K L

出版信息

Plast Reconstr Surg. 1975 Mar;55(3):294-8.

PMID:1118487
Abstract

An attempt was made to produce tumor immunity in 193 patients who had melanoma, 160 of whom had metastases and 33 of whom did not. Four stages of treatment are outlined. The patients whose disease was confined to the skin, subcutaneous tissues, and lymph nodes seemed to benefit most. The treatment was of no benefit to patients whose disease had progressed to the visceral, skeletal, or central nervous systems.

摘要

对193例黑色素瘤患者进行了诱导肿瘤免疫的尝试,其中160例有转移,33例无转移。概述了四个治疗阶段。疾病局限于皮肤、皮下组织和淋巴结的患者似乎获益最大。对于疾病已进展至内脏、骨骼或中枢神经系统的患者,该治疗无效。

相似文献

1
Intralesional BCG, intravenous immune lymphocytes, and immunization with neuraminidase-treated tumor cells to manage melanoma; A clinical assessment.瘤内注射卡介苗、静脉注射免疫淋巴细胞以及用神经氨酸酶处理的肿瘤细胞进行免疫治疗黑色素瘤;一项临床评估。
Plast Reconstr Surg. 1975 Mar;55(3):294-8.
2
[Immunological aspects of melanoma].[黑色素瘤的免疫学方面]
Lakartidningen. 1976 Feb 11;73(7):528-30.
3
In vitro assay of cell-mediated immunity in BCG therapy of malignant melanoma: a preliminary report.卡介苗治疗恶性黑色素瘤的细胞介导免疫体外测定:初步报告。
Natl Cancer Inst Monogr. 1973 Dec;39:221-4.
4
Immunology and cutaneous malignant melanoma.免疫学与皮肤恶性黑色素瘤
Int J Dermatol. 1976 Jan-Feb;15(1):1-18. doi: 10.1111/j.1365-4362.1976.tb05089.x.
5
Progress of immunotherapy in the treatment of malignant melanoma.免疫疗法在恶性黑色素瘤治疗中的进展
Yale J Biol Med. 1975 Nov;48(5):423-9.
6
The immune response in human malignant melanoma.人类恶性黑色素瘤中的免疫反应。
Clin Exp Dermatol. 1976 Mar;1(1):23-8. doi: 10.1111/j.1365-2230.1976.tb01395.x.
7
Immune response and non-specific immunotherapy in melanoma.黑色素瘤中的免疫反应与非特异性免疫疗法
Ann R Coll Surg Engl. 1978 Mar;60(2):117-20.
8
The immunologic and histopathologic changes of BCG-mediated tumor regression in patients with malignant melanoma.恶性黑色素瘤患者中卡介苗介导的肿瘤消退的免疫和组织病理学变化。
Cancer. 1975 Mar;35(3):756-77. doi: 10.1002/1097-0142(197503)35:3<756::aid-cncr2820350331>3.0.co;2-z.
9
[Immunology of melanoma].[黑色素瘤的免疫学]
Acta Chir Belg. 1974 Mar;73(2):135-88.
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Active specific and active non-specific immunotherapy in patients with malignant melanoma.恶性黑色素瘤患者的主动特异性和主动非特异性免疫治疗
Oncology. 1977;34(5):229-33. doi: 10.1159/000225230.

引用本文的文献

1
Intralesional treatment of metastatic melanoma: a review of therapeutic options.转移性黑色素瘤的瘤内治疗:治疗选择综述
Cancer Immunol Immunother. 2017 May;66(5):647-656. doi: 10.1007/s00262-016-1952-0. Epub 2017 Jan 11.
2
Developments in Intralesional Therapy for Metastatic Melanoma.转移性黑色素瘤瘤内治疗的进展
Cancer Control. 2016 Jan;23(1):12-20. doi: 10.1177/107327481602300104.
3
Melanoma vaccines and modulation of the immune system in the clinical setting: building from new realities.黑素瘤疫苗与免疫系统在临床环境中的调节:基于新现实。
Front Immunol. 2012 May 4;3:103. doi: 10.3389/fimmu.2012.00103. eCollection 2012.