Yamamoto K, Kikuchi Y, Kudoh K, Hirata J, Kita T, Nagata I
Department of Obstetrics and Gynecology, National Defense Medical College, Tokorozawa, Saitama, Japan.
Jpn J Clin Oncol. 2000 Oct;30(10):446-9.
We have previously reported that paclitaxel (taxol) results in cisplatin sensitization to human ovarian cancer cells with cisplatin resistance in vitro. This study was designed to determine effects of taxol and its combination with cisplatin on growth of cisplatin-sensitive cell line (KF28) and the cisplatin-resistant counterpart (KFr13) in nude mice.
From 14 days after tumor inoculation treatment was initiated. Taxol (3 mg/kg) and cisplatin (2 mg/kg) were administered i.p. once a week for 5 weeks.
In nude mice bearing cisplatin-sensitive cells (KF28), taxol followed by cisplatin and cisplatin plus taxol inhibited significantly (P < 0.05) the tumor growth rate compared with that in nude mice treated with cisplatin alone or taxol alone and cisplatin followed by taxol. On the other hand, in nude mice bearing cisplatin-resistant KFr13 cells, treatment with taxol alone inhibited completely the tumor growth rate, whereas no schedule-dependent interaction of taxol with cisplatin was observed.
These results suggest that treatment with taxol alone may be superior to combination of taxol with cisplatin in patients with cisplatin-resistant ovarian carcinoma.
我们之前报道过，紫杉醇（泰素）在体外可使对顺铂耐药的人卵巢癌细胞对顺铂敏感。本研究旨在确定紫杉醇及其与顺铂联合应用对裸鼠体内顺铂敏感细胞系（KF28）和顺铂耐药细胞系（KFr13）生长的影响。
在肿瘤接种后14天开始进行治疗。紫杉醇（3mg/kg）和顺铂（2mg/kg）腹腔注射给药，每周一次，共5周。
在接种顺铂敏感细胞（KF28）的裸鼠中，与单独使用顺铂、单独使用紫杉醇以及先顺铂后紫杉醇治疗的裸鼠相比，先紫杉醇后顺铂以及顺铂加紫杉醇治疗显著（P<0.05）抑制了肿瘤生长速率。另一方面，在接种顺铂耐药KFr13细胞的裸鼠中，单独使用紫杉醇治疗完全抑制了肿瘤生长速率，而未观察到紫杉醇与顺铂有依赖给药顺序的相互作用。
这些结果表明，对于顺铂耐药的卵巢癌患者，单独使用紫杉醇治疗可能优于紫杉醇与顺铂联合治疗。
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