[nm23-H1和p53蛋白在鼻咽癌中的表达]
[The expression of nm23-H1 and p53 protein in nasopharyngeal carcinoma].
作者信息
Zhou Y, Xu A, Ling X
机构信息
Department of Pathology, Guilin Medical College, Guilin 541001.
出版信息
Lin Chuang Er Bi Yan Hou Ke Za Zhi. 1998 Jun;12(6):243-6.
UNLABELLED
To evaluate the role of nm23-H1 and p53 protein expression in Nasopharyngeal Carcinoma (NPC), the S-P immunohistochemical method was used to detect the expression of nm23-H1 and p53 protein in 125 cases of NPC.
RESULTS
The positive expression for nm23-H1 and p53 were 50.4%(63/125), 90.4%(113/125), respectively nm23-H1 expression in the NPC with cervical lymph node metastasis and without cervical lymph node metastasis were 27.9%(17/61) and 71.9%(46/64), respectively (P < 0.001).
CONCLUSION
- Mutations of p53 may play a role in carcinogenesis of NPC. 2. The difference between the NPC with cervical lymph node metastasis and without cervical lymph node metastasis for nm23-H1 expression was significant. The nm23-H1 gene may play a role in antimetastasis of NPC.
未标记
为评估nm23-H1和p53蛋白表达在鼻咽癌（NPC）中的作用，采用S-P免疫组化方法检测125例NPC中nm23-H1和p53蛋白的表达。
结果
nm23-H1和p53的阳性表达分别为50.4%（63/125）、90.4%（113/125）。有颈部淋巴结转移的NPC中nm23-H1表达为27.9%（17/61），无颈部淋巴结转移的NPC中nm23-H1表达为71.9%（46/64），差异有统计学意义（P<0.001）。
结论
- p53突变可能在NPC的发生中起作用。2. 有颈部淋巴结转移和无颈部淋巴结转移的NPC中nm23-H1表达差异有统计学意义。nm23-H1基因可能在NPC的抗转移中起作用。
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