Dredán J, Fekete R, Zelkó R, Rácz I, Marton S
Pharmaceutical Institute, Semmelweis University of Medicine Budapest, Hungary.
Pharmazie. 2000 Dec;55(12):925-7.
The purpose of the present work was to study the relationship between the physicochemical characteristics of different polyethylene glycol aqueous solutions and the kinetics of potassium chloride release from wax matrix samples containing polyethylene glycol derivatives. Potassium chloride was embedded into thermosoftening matrix material to produce a sustained-release dosage form. Potassium chloride release was measured by the rotating paddle method of USP 23 and the dissolution process was characterized by a modified Nernst equation. Physicochemical characteristics--surface tension, dynamic contact angle, viscosity--of the polyethylene glycol aqueous solutions were also determined. The results indicate that the adhesion tension of surfactant containing aqueous solutions has a decisive impact on the prediction of the potassium chloride release rate from wax matrices.
本研究的目的是探讨不同聚乙二醇水溶液的物理化学特性与含聚乙二醇衍生物的蜡基质样品中氯化钾释放动力学之间的关系。将氯化钾包埋于热软化基质材料中以制备缓释剂型。采用美国药典23版的转桨法测定氯化钾的释放，并通过修正的能斯特方程对溶解过程进行表征。还测定了聚乙二醇水溶液的物理化学特性——表面张力、动态接触角、粘度。结果表明，含表面活性剂水溶液的粘附张力对预测蜡基质中氯化钾的释放速率具有决定性影响。
