随着水杨酸盐的存在，对夫西地酸耐药的金黄色葡萄球菌出现的突变频率增加。
Increases in the mutation frequency at which fusidic acid-resistant Staphylococcus aureus arise with salicylate.
作者信息
Price Christopher T D, Gustafson John E
机构信息
*Microbiology Group, School of Biomedical Sciences, Curtin University of Technology, Perth 6845, Western Australia and †Department of Microbiology, Chicago College of Osteopathic Medicine, Midwestern University, Downers Grove, IL 60515, USA.
出版信息
J Med Microbiol. 2001 Jan;50(1):104-106. doi: 10.1099/0022-1317-50-1-104.
Salicylate was shown to increase the frequency at which a fusidic acid-susceptible strain of Staphylococcus aureus underwent mutation to become fusidic acid-resistant. These fusidic acid-resistant mutants had alterations in spectinomycin and kanamycin resistance levels indicative of mutations in fusA, the gene that encodes elongation factor-G, the target of fusidic acid.
水杨酸盐被证明可增加金黄色葡萄球菌对夫西地酸敏感菌株发生突变而变得对夫西地酸耐药的频率。这些对夫西地酸耐药的突变体在壮观霉素和卡那霉素耐药水平上有改变，这表明fusA基因发生了突变，fusA基因编码延伸因子G，而延伸因子G是夫西地酸的作用靶点。
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