一株对夫西地酸耐药的金黄色葡萄球菌流行菌株携带fusB决定簇，而fusA突变在其他耐药分离株中很普遍。
A fusidic acid-resistant epidemic strain of Staphylococcus aureus carries the fusB determinant, whereas fusA mutations are prevalent in other resistant isolates.
作者信息
O'Neill Alexander J, Larsen Anders R, Henriksen Anne S, Chopra Ian
机构信息
Antimicrobial Research Centre and School of Biochemistry and Microbiology, University of Leeds, Leeds LS2 9JT, UK.
出版信息
Antimicrob Agents Chemother. 2004 Sep;48(9):3594-7. doi: 10.1128/AAC.48.9.3594-3597.2004.
Abstract
Fusidic acid-resistant epidemic Staphylococcus aureus strains causing impetigo bullosa have been reported in Scandinavia. We show that these strains form part of a European epidemic clonotype that carries the fusB determinant. In contrast, resistance to fusidic acid in a collection of nonepidemic strains resulted primarily from mutations in fusA.
摘要
在斯堪的纳维亚半岛已报道了引起大疱性脓疱病的耐夫西地酸流行金黄色葡萄球菌菌株。我们发现这些菌株是携带fusB决定簇的欧洲流行克隆型的一部分。相比之下，一组非流行菌株对夫西地酸的耐药性主要源于fusA的突变。
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