Siemiatkowski M, Rokicki D, Członkowska A I, Sienkiewicz-Jarosz H, Bidziński A, Płaźnik A
Department of Pharmacology and Physiology of the Nervous System, Institute of Psychiatry and Neurology, Warsaw, Poland.
Neuroreport. 2000 Dec 18;11(18):3953-6.
Rat behavior in the open field and conditioned fear response test was correlated with specific binding of dopamine D1 receptor antagonist [3H]SCH 23390 within different brain structures assayed with autoradiography. A significant positive correlation was found between the ligand binding in the substantia nigra pars reticulata and both animal motor activity (r = 0.67, p < 0.05) and the number of entries into the central sector of the open field (r = 0.59, p < 0.05). On the other hand, rat motility and the central entries were negatively correlated with [3H]SCH 23390 binding within the caudate putamen (r = -0.64, p < 0.05 and r = -0.61 p <0.05, respectively). No correlation was revealed between the ligand binding in the examined brain areas and freezing reaction in the contextual fear conditioning test. The present data indicate for the first time a significant, structure-dependent correlation between rat motor behavior and the dopamine D1 receptor ligand binding within the nigrostriatal system.
在旷场实验和条件性恐惧反应测试中，大鼠的行为与用放射自显影法测定的不同脑区中多巴胺D1受体拮抗剂[3H]SCH 23390的特异性结合相关。在黑质网状部的配体结合与动物运动活性（r = 0.67，p < 0.05）以及进入旷场中央区域的次数（r = 0.59，p < 0.05）之间均发现显著正相关。另一方面，大鼠的运动能力和进入中央区域的次数与尾壳核内的[3H]SCH 23390结合呈负相关（分别为r = -0.64，p < 0.05和r = -0.61，p < 0.05）。在所检测的脑区中的配体结合与情境性恐惧条件反射测试中的僵住反应之间未发现相关性。目前的数据首次表明大鼠运动行为与黑质纹状体系统内多巴胺D1受体配体结合之间存在显著的、结构依赖性的相关性。
