Mazeron J J, Simon J M, Noël G, Proudhom M A, Renard A
Centre des tumeurs, groupe hospitalier Pitié-Salpêtrière, 47-83, boulevard de l'Hôpital, 75651 Paris, France.
Cancer Radiother. 2000 Nov;4 Suppl 1:53s-66s.
Gliomas are moderately radiosensitive. The main prognostic factors are the anatomicopathological type and grade of glioma, the performance status, age of the patient and the extent of the surgery. According to data from the literature, high-grade gliomas should be given 60 Gy in five weekly fractions of 1.7 to 2 Gy in a volume including tumor or tumor bed, edema and a 2- to 3-cm margin. A dose of 45 Gy would be sufficient for low-grade gliomas, according to the results of a recent randomized EORTC trial. Brachytherapy and radiosurgery techniques may be indicated in selected cases.
胶质瘤具有中度放射敏感性。主要的预后因素包括胶质瘤的解剖病理学类型和分级、患者的身体状况、年龄以及手术范围。根据文献数据,对于高级别胶质瘤,应在包含肿瘤或肿瘤床、水肿以及2至3厘米边缘的体积内,每周分5次给予60 Gy,每次剂量为1.7至2 Gy。根据欧洲癌症研究与治疗组织(EORTC)最近一项随机试验的结果,45 Gy的剂量对低级别胶质瘤就足够了。在某些特定情况下,可能会采用近距离放疗和放射外科技术。