Wendt T G, Bacherler B, Baumer K, Rohloff R, Willich N
Strahlenther Onkol. 1986 Jun;162(6):347-53.
Between 1970 and 1983, 149 patients with high grade anaplastic supratentorial gliomas received a postoperative irradiation during primary treatment. 118 out of these patients had an anaplastic astrocytoma, 18 an anaplastic oligodendroglioma, and 13 an anaplastic ependymoma. Most of these patients were treated by irradiation of a great volume with 50 Gy within five weeks, the others by irradiation of the total brain with 50 Gy within five weeks and saturation with 10 Gy within one week. The one-year survival of the total group was 35.5% and the two-year survival 10.6%. Patients at an age of less than 40 years show a significantly longer survival than older patients (one-year survival rates 40% and 30.7%, respectively). Patients suffering from anaplastic tumors with astrocytic and oligodendrocytic differentiation have a comparable prognosis. Patients suffering from anaplastic tumors with ependymal differentiation, however, have prolonged survival times. The therapy results of different treatment methods are discussed using the communications of literature.
1970年至1983年间,149例幕上高级别间变性胶质瘤患者在初始治疗期间接受了术后放疗。其中118例为间变性星形细胞瘤,18例为间变性少突胶质细胞瘤,13例为间变性室管膜瘤。这些患者大多在五周内接受50 Gy大体积照射,其余患者在五周内接受全脑50 Gy照射并在一周内追加10 Gy。全组患者的一年生存率为35.5%,两年生存率为10.6%。年龄小于40岁的患者生存率明显高于老年患者(一年生存率分别为40%和30.7%)。具有星形细胞和少突胶质细胞分化的间变性肿瘤患者预后相当。然而,具有室管膜分化的间变性肿瘤患者生存期延长。结合文献报道讨论了不同治疗方法的治疗结果。