Yano K, Miki Y
Department of Molecular Diagnosis, Cancer Institute, Japanese Foundation for Cancer Research.
Nihon Rinsho. 2001 Jan;59(1):31-7.
Carcinogenesis is a multistep process which is the outcome of the accumulation of genetic and epigenetic events. However, characteristics of cancers, such as drug sensitivity, abilities in invasion and metastasis, are different in each patients, and reliable prediction of those characteristics is not available. DNA microarray and SNP have become the most widely used functional genomics tools. Microarray technology has provided the ability to analyse the expression profiles for thousands of genes, and a wealth of new information that should aid in cancer diagnosis and ultimately in therapy. The SNP project also will generate very variable resources for cancer therapy. The medicine in the next century will be so called 'personalized medicine' based on the new information of patients and diseases.
癌症发生是一个多步骤过程，是遗传和表观遗传事件积累的结果。然而，癌症的特征，如药物敏感性、侵袭和转移能力，在每个患者中都有所不同，并且无法对这些特征进行可靠预测。DNA微阵列和单核苷酸多态性（SNP）已成为使用最广泛的功能基因组学工具。微阵列技术使分析数千个基因的表达谱成为可能，并提供了大量有助于癌症诊断及最终治疗的新信息。SNP项目也将为癌症治疗产生非常多样的资源。基于患者和疾病的新信息，下个世纪的医学将是所谓的“个性化医学”。
