Kassubek J, Juengling F D, Nitzsche E U, Lücking C H
Department of Neurology, University of Freiburg, Breisacher Str. 64, 79106 Freiburg, Germany.
J Neuroimaging. 2001 Jan;11(1):55-9. doi: 10.1111/j.1552-6569.2001.tb00011.x.
Two patients with clinically probable or possible limbic encephalitis (LE) are reported, both cases with typical findings in clinical symptoms (severe neuropsychological deficits and complex partial seizures) and in routine magnetic resonance imaging (MRI) (hyperintense mesiotemporal lesions). Underlying malignancy was identified (rectal carcinoma) in one case but could not be detected in the other patient. The 2 patients were investigated by cerebral 18F-fluoro-2-deoxy-D-glucose-positron emission tomography (FDG-PET) and 3-dimensional (3D) MRI, and abnormalities in metabolic activity were mapped using coregistration of spatially normalized PET and MRI. Highly significant focal hypermetabolism in bilateral hippocampal areas was found in both cases. The authors' findings support FDG-PET coregistered to 3D MRI as a potentially valuable additional tool in the imaging diagnostics of LE. Results are discussed with respect to the clinical symptoms and previously reported imaging findings in the disease.
本文报告了两名临床诊断为可能或疑似边缘叶脑炎（LE）的患者，这两例患者在临床症状（严重神经心理缺陷和复杂部分性癫痫发作）及常规磁共振成像（MRI）（内侧颞叶高信号病变）方面均有典型表现。其中一例患者确诊存在潜在恶性肿瘤（直肠癌），而另一例未检测到。对这两名患者进行了脑18F-氟-2-脱氧-D-葡萄糖正电子发射断层扫描（FDG-PET）及三维（3D）MRI检查，并通过空间归一化PET与MRI的配准来描绘代谢活性异常情况。两例患者均发现双侧海马区存在高度显著的局灶性代谢亢进。作者的研究结果支持将FDG-PET与3D MRI配准作为LE影像诊断中一种潜在有价值的辅助工具。结合该疾病的临床症状及先前报道的影像结果对研究结果进行了讨论。
