Hancox R J, Whyte K F, Baxter J M
Department of Respiratory Medicine, Green Lane Hospital, Auckland.
N Z Med J. 2000 Nov 24;113(1122):500-3.
To describe the characteristics and outcomes of patients treated with domiciliary nocturnal support ventilation (NSV).
Case-note review of all patients treated with home NSV by Green Lane Hospital.
111 patients received home NSV between 1990 and 1999. 59 had respiratory failure due to obesity-hypoventilation syndrome (OHS), most of whom were Maori or Pacific Island people. Their mean BMI was 53 kg/m2. They frequently presented acutely, and often in extremis. After a median duration of 22 months treatment, 37 patients continued treatment. Four have died, but none from respiratory failure. Other causes of respiratory failure included: neuromuscular disease (26), kyphoscoliosis (19) and obstructive sleep apnoea (8). Patients who did not have OHS were mostly of New Zealand European ethnicity, required lower ventilation pressures than patients with OHS, and had better arterial blood gases on treatment. After a median follow-up of 35 months, however, fourteen have died. 33 continued on treatment. Both OHS and non-OHS patients had high deprivation scores according to NZdep96. This was most apparent for patients with OHS.
OHS is an important cause of respiratory failure in New Zealand, particularly affecting Maori and Pacific people. The prognosis of OHS treated with NSV appears to be good despite significant co-morbidity.
描述接受家庭夜间支持通气（NSV）治疗的患者的特征和治疗结果。
对格林莱恩医院所有接受家庭NSV治疗的患者进行病历回顾。
1990年至1999年间，111例患者接受了家庭NSV治疗。59例因肥胖低通气综合征（OHS）导致呼吸衰竭，其中大多数是毛利人或太平洋岛民。他们的平均体重指数为53kg/m²。他们经常急性发病，且常常处于危急状态。经过中位时间22个月的治疗后，37例患者继续接受治疗。4例患者死亡，但均非死于呼吸衰竭。呼吸衰竭的其他原因包括：神经肌肉疾病（26例）、脊柱后侧凸（19例）和阻塞性睡眠呼吸暂停（8例）。没有OHS的患者大多是新西兰欧洲族裔，所需通气压力低于OHS患者，治疗时动脉血气情况较好。然而，经过中位35个月的随访，14例患者死亡。33例患者继续接受治疗。根据NZdep96，OHS患者和非OHS患者的贫困得分都很高。这在OHS患者中最为明显。
OHS是新西兰呼吸衰竭的一个重要原因，尤其影响毛利人和太平洋岛民。尽管存在显著的合并症，但NSV治疗OHS的预后似乎良好。
