Moyano Calvo J L, de Miguel Rodríguez M, Ortiz Gamiz A, Poyato Galán J M, Sánchez Sánchez E, Blanco Palenciano E, Arribas Rodríguez J M, Galera Davidson H, Castiñeiras Fernández J
Servicio de Urología, Hospital Universitario Virgen Macarena, Sevilla.
Actas Urol Esp. 2000 Nov-Dec;24(10):785-95.
Observe the correlation between Ki-67 label index, p53 expression and flow cytometry-DNA ploidy with the classic variables (grade, lymphatic permeation, multiplicity, volume, primary).
121 superficial bladder tumors T1. 10% Cut-off level for Ki-67 and p53. Aneuploidy is defined as a tumor with DNA index different of 1 or more than 20% in G2-M phase.
Statistical correlation with grade and lymphatic permeation. Ki-67 label index and p53 expression can distinguish between G1, G2 vs G3 and Lx, L0 vs. L1. The volume correlates with positivity to p53.
Aneuploidy and positivity to Ki-67 and p53 increase with grade and lymphatic permeation.
观察Ki-67标记指数、p53表达与流式细胞术-DNA倍体与经典变量（分级、淋巴浸润、多灶性、体积、原发灶）之间的相关性。
121例浅表性膀胱T1期肿瘤。Ki-67和p53的截断水平为10%。非整倍体定义为DNA指数在G2-M期不同于1或超过20%的肿瘤。
与分级和淋巴浸润存在统计学相关性。Ki-67标记指数和p53表达可区分G1、G2与G3以及Lx、L0与L1。体积与p53阳性相关。
非整倍体以及Ki-67和p53阳性随分级和淋巴浸润增加。
