Sugiyama M, Ito J, Aoyagi S, Fukuda H
Botanical Gardens, Graduate School of Science, Tle University of Tokyo, Japan.
Plant Mol Biol. 2000 Oct;44(3):387-97. doi: 10.1023/a:1026504911786.
Programmed cell death (PCD) involves hydrolysis of genomic DNA, which must be catalyzed by endonuclease(s) capable of digesting dsDNA. Plants have two major classes of endonucleases active towards dsDNA, Zn2+-dependent endonuclease and Ca2+-dependent endonuclease. Both classes are found among endonucleases nominated for machineries of PCD in plants. Survey of plant endonucleases in relation to PCD leads to a possibility that a different class of endonuclease reflects a different phase of PCD-associated DNA hydrolysis.
程序性细胞死亡（PCD）涉及基因组DNA的水解，这必须由能够消化双链DNA的核酸内切酶催化。植物有两类对双链DNA有活性的主要核酸内切酶，即锌离子依赖性核酸内切酶和钙离子依赖性核酸内切酶。在被指定参与植物PCD机制的核酸内切酶中都发现了这两类酶。对与PCD相关的植物核酸内切酶的研究表明，不同类型的核酸内切酶可能反映了PCD相关DNA水解的不同阶段。
