Jaworska H, Gregorek H, Madaliński K
Zakład Immunologii Klinicznej Instytutu-Pomnika Centrum Zdrowia Dziecka w Warszawie.
Przegl Lek. 2000;57(9):483-8.
Deficit of the first component of complement inhibitor (C1-inhibitor, C1-inh) may clinically be manifested as angioedema. The disease is characterized by episodic swellings of mucosa and subcutaneous tissue at different locations of the body. Laryngeal swelling can be life-threatening. The major mediators of edema are discussed to be bradykinin and C2b derived peptides. These mediators increase capillary permeability. Antifibrinolytic agents (aminocaproic acid, tranexamic acid) and attenuated androgens (danazol or stanazolol) are used for prophylaxis. Prolonged use both of them might result in more or less severe side effects. In experiments in vitro it has been shown that IFN-gamma, IL-1, IL-6 have a stimulatory effect on C1-inh synthesis. We want to verify the practical use of probiotics as natural inductors of IFN-gamma synthesis for elevating C1-inh level.
补体抑制剂的第一个成分（C1-抑制剂，C1-inh）缺乏在临床上可能表现为血管性水肿。该疾病的特征是身体不同部位的黏膜和皮下组织出现间歇性肿胀。喉部肿胀可能危及生命。水肿的主要介质被认为是缓激肽和C2b衍生肽。这些介质会增加毛细血管通透性。抗纤维蛋白溶解剂（氨基己酸、氨甲环酸）和弱雄激素（达那唑或司坦唑醇）用于预防。长期使用这两种药物都可能导致或多或少的严重副作用。体外实验表明，IFN-γ、IL-1、IL-6对C1-inh的合成有刺激作用。我们想验证益生菌作为IFN-γ合成的天然诱导剂提高C1-inh水平的实际用途。
