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Synthesis and antiviral evaluation of the beta-L-enantiomers of some thymine 3'-deoxypentofuranonucleoside derivatives.

作者信息

Mathé C, Gosselin G

机构信息

Laboratoire de Chimie Organique Biomoléculaire de Synthèse, UMR 5625 CNRS-UM-II, Université Montpellier II, Sciences et Techniques du Languedoc, France.

出版信息

Nucleosides Nucleotides Nucleic Acids. 2000 Oct-Dec;19(10-12):1517-30. doi: 10.1080/15257770008045443.

DOI:10.1080/15257770008045443
PMID:11200256
Abstract

3'-Deoxy-beta-L-erythro- (3), 3'-deoxy-beta-L-threo- (6), 2'-fluoro- (7) and 2'-azido-2',3'-dideoxy-beta-L-erythro- (10) pentofuranonucleoside derivatives of thymine have been synthesized and their antiviral properties examined. All these derivatives were stereospecifically prepared by glycosylation of thymine with a suitable peracylated 3-deoxy-L-erythro-pentofuranose sugar (1), followed by appropriate chemical modifications. The prepared compounds were tested for their activity against HIV, but they did not show an antiviral effect.

摘要

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