脱氢表雄酮新类似物免疫调节剂（IM28）对人类免疫缺陷病毒1型（HIV-1）复制的抑制作用
Inhibition of human immunodeficiency virus type-1 (HIV-1) replication by immunor (IM28), a new analog of dehydroepiandrosterone.
作者信息
Diallo K, Loemba H, Oliveira M, Mavoungou D D, Wainberg M A
机构信息
McGill AIDS Centre, Jewish General Hospital, Montreal, Quebec, Canada.
出版信息
Nucleosides Nucleotides Nucleic Acids. 2000 Oct-Dec;19(10-12):2019-24. doi: 10.1080/15257770008045475.
The inhibition of HIV-1 replication in vitro by Immunor 28 (IM28), an analog of dehydroepiandrosterone (DHEA), was monitored using the HIV-1 laboratory wild-type strain IIIB. Evaluation of the 50% inhibitory dose (IC50) revealed a decrease in HIV-1 replication giving an IC50 value around 22 microM. The toxicity of the drug has been determined also, in MT2 cells and PBMCs. 60 microM of IM28 provoked a 50% decrease in cell viability while DHEA caused the same decrease at 75 microM in MT2 cells. These values are 125 microM for IM28 in PBMCs and 135 microM for DHEA. Thus, DHEA is less toxic than IM28, but IM28 has a higher antiviral activity.
使用HIV-1实验室野生型菌株IIIB监测脱氢表雄酮（DHEA）类似物Immunor 28（IM28）在体外对HIV-1复制的抑制作用。对50%抑制浓度（IC50）的评估显示，HIV-1复制减少，IC50值约为22微摩尔。还在MT2细胞和外周血单核细胞（PBMC）中测定了该药物的毒性。60微摩尔的IM28可使MT2细胞的细胞活力降低50%，而DHEA在MT2细胞中浓度为75微摩尔时会导致相同程度的降低。在PBMC中，IM28的这些值为125微摩尔，DHEA为135微摩尔。因此，DHEA的毒性低于IM28，但IM28具有更高的抗病毒活性。
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